N-(2-Chlorophenyl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
نویسندگان
چکیده
منابع مشابه
4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3- carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors
4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) as nonsteroidal antiinflammatory drug (NSAIDs) of oxicam family has been synthesized bearing high selectivity for cyclooxygenase-2 (COX-2) inhibition and high ability to chelate with Cu(II) ions. The EX15Cu(II) complex, and [Cu(EX15)(OAc)(H2O)2], were synthesized and characterized by using elemental analysis...
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In the title compound, C(17)H(15)N(3)O(5)S, the thia-zine ring adopts a distorted half-chair conformation. The mol-ecular structure is stabilized by intra-molecular N-H⋯O, N-H⋯N and O-H⋯O hydrogen bonding. Pairs of mol-ecules are bound together as centrosymmetric dimers through N-H⋯O hydrogen bonds.
متن کاملN-(3,4-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
1,2-Benzothia-zines similar to the title compound, C(18)H(18)N(2)O(4)S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thia-zine ring adopts a distorted half-chair conformation. The enolic H atom is involved in an intra-molecular O-H⋯O hydrogen bond, forming a six-membered ring. In the cry...
متن کاملN-(2-Chlorophenyl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
In the title compound, C(15)H(11)ClN(2)O(4)S, there are two independent mol-ecules in the asymmetric unit, in which the heterocyclic thia-zine rings in both mol-ecules adopt half-chair conformations. The conformations about the C-C and C-N bonds in the central C-C-N-C chain in both mol-ecules are all EZ. There are strong intra-molecular O-H⋯O and N-H⋯N hydrogen bonds resulting in graph-set patt...
متن کاملN-Butyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
The title compound, C(14)H(18)N(2)O(4)S, contains hydrogen-bonded dimeric pairs of mol-ecules arranged around inversion centers, forming 14-membered rings with an R(2) (2)(14) motif. The structure is stabilized by extensive intra-molecular inter-actions. The thia-zine ring adopts a half-chair conformation, with the S and N atoms displaced by -0.485 (3) and 0.296 (3) Å, respectively, from the pl...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2009
ISSN: 1600-5368
DOI: 10.1107/s1600536809033972